Nowadays, drought is known as one of the environmental phenomena that has important impact on water quality. The aim of this study was to obtain a relationship between drought and water quality in Zayande-Roud watershed. With respect to the impact of droughton water qualityand also determining the type of water and its relationship with environmental factors, in this study, chemical characteristics of water were investigated using AqQasoftware. Then, chemical type of water resources and its relationship between drought and water quality was determined. The study area was Zayande-Roud River that has five hydrometric stations with 34 years common data. Two stations were located before dam and three stations after dam. In this period, using drought indices (SPI and RDI), dry and wet years were separated from each other, then maximum common dry and wet years were determined in five stations. Then, water quality data were compared in dry and wet years. Based on the results obtained, with the occurrence of drought, the concentration of ions in water has increased and in wet years the concentration of ions in water has improved. As example in Eskandari station, magnesium ion has increased by about 37% in dry years and the rate of sulfate ion in Pol-e-Zaman Khan station has increased by 56% in dry years. Water type in each station was sodium bicarbonate that can be related to geological factors.